View Vacancy -- MRC Postdoctoral Scientist LMS 1086

Open Date
17/05/2019, 14:40
Close Date
19/06/2019, 23:55
MRC London Institute of Medical Science

The London Institute of Medical Sciences (LMS) at Hammersmith Hospital is the third directly funded MRC research institute and enjoys close links with its partners at Imperial College and at the Imperial College Healthcare NHS Trust. The LMS research focuses on strengthening the basic science underpinning our understanding of human diseases and the translation of such high quality research into a clinical setting.

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org

MRC - 4
London
£35,859 - £38,700 pa inclusive*
Fixed Term
Science
Full Time
3 years

Overall purpose:

The Cell Cycle Control team, headed by Dr Alexis Barr, aims to understand how cells enter and exit the cell cycle. Getting the balance between proliferation and quiescence right is vital for normal development and in maintaining tissue homeostasis. We are focussed on understanding how extracellular and intracellular factors impact cyclin-dependent kinase (CDK) activity to drive cell cycle decision-making. Since many of these control networks are dysregulated in cancer, our work could influence how tumours are treated to prevent uncontrolled proliferation of cancer cells.

To address our research questions, we use a combination of high-content fixed and live single-cell imaging, quantitative image analysis, CRISPR/Cas9-mediated genetic engineering, proteomics and screening.

Job Summary

The successful candidate will be a key member of the Cell Cycle Control group, and will enjoy a high level of scientific responsibility. They will work in a focussed and organised manner to produce independent and original research within the group, deliver the scientific aims of the project and aid in the submission of publications to refereed journals. They will also help with supervising students and contribute to the smooth running of the research group.

Main Responsibilities:

  • To plan, carry out, and analyse research in accordance with the agreed project aims.
  • To attend all lab and related research meetings, and to present work when required.
  • To attend and contribute to journal clubs and seminar presentations.
  • To keep up to date with the scientific literature and technical advances relevant to the project.
  • To present data at national and international meetings (where and when appropriate).
  • To interact and collaborate with researchers in related projects.
  • To take an active part in the academic activities of the LMS.
  • To write up work for publication in peer-reviewed journals.
  • To form good working relationships with other members of the group, as well as internal and external collaborators.
  • To assist others and co-supervise students when required.
  • To contribute to the development and maintenance of the group’s experimental infrastructure as appropriate.
  • To help with the daily running of the lab by assisting with general lab duties as required.

This is an MRC Postdoctoral Scientist position providing training and development supporting post-doctoral scientists in early or changed career paths helping establish them as successful research scientists in their chosen field.

Applicants must have a PhD or equivalent experience in a relevant life sciences, systems biology or biomedical discipline and extensive experience in cell culture and molecular biology techniques. An excellent track record of independent research is also essential. Expertise in cell cycle, cellular quiescence, genome stability, cell signalling and/or quantitative image analysis would be an advantage. The successful candidate must also have the ability to develop and apply new concepts, have a creative approach to problem solving, and be able to write clearly and succinctly for publication

Education / Qualifications / Training required (will be assessed from application form):

Essential:

  • PhD (or equivalent experience) in a relevant life sciences, systems biology, biomedical or related discipline.

Previous work experience required (will be assessed from application form and at interview):

Essential:

  • Extensive experience in cell culture
  • Extensive experience in molecular biology techniques
  • Previous experience in one or more of the following areas:
  1. -       Cell cycle, cell proliferation, cellular quiescence
  2. -       Genome stability
  3. -       Cell signalling
  4. -       Light microscopy and quantitative image analysis
  5. -       CRISPR gene editing
  6. -       Biochemical techniques, including in vitro kinase assays, proteomics

 

Knowledge and experience (will be assessed from application form and at interview):

Essential:

  • A keen interest in cell cycle control and cell signalling
  • An excellent track record of independent research
  • Excellent written and verbal communication skills, ability to write clearly and succinctly for publication

Desirable:

A first author publication in an international, peer-reviewed journal

 

Personal skills/behaviours/qualities (will be assessed at the interview):

Essential:

  • Ability to work independently and as part of a team (both in situ and remotely with national and international collaborators)
  • Evidence of ability to conduct research independently, from the planning stages, execution, troubleshooting and write-up
  • Desire to learn and acquire new skills and to pro-actively seek novel and creative solutions to scientific problems
  • Willingness to share knowledge and skills with other members of the group on a daily basis
  • Good written and verbal communication skills in English
  • Ability to constructively criticise one’s own and others results

Applicants should submit CV with a brief cover letter describing how the candidate fits the person specifications and motivation for the post and names and contacts of two scientific references. Please do not send reference letters at this stage.

*Salary quoted is inclusive of London weighting. Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.


The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.

We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.

This opportunity is closed to applications.