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View Vacancy -- Histology Research Officer - TOX - 713

Open Date
17/11/2017, 15:00
Close Date
04/12/2017, 23:55
MRC Toxicology Unit

The Medical Research Council Toxicology Unit, located at the University of Leicester, is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The histology unit is expanding, and houses state-of-the art facilities for research histological methods.

The Unit is currently in the process of transferring to the University of Cambridge. Legal transfer will take place in March 2018; the physical relocation is expected to take place in early 2020.


UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org

MRC - 5
£22,201 - £25,976
Fixed Term
Full Time
3 Years

We are looking to appoint a Histology Research Officer to join the core facility which provides specialist histology support to research groups within the MRC Toxicology Unit.

This position is a three year contract funded by Celgene.

Overall purpose:

To provide a specialist histology support to the research programme of the Toxicology Unit which comprises of approximately 120 employees and students.

Working relationships:

The post holder reports directly to the Histopathology Laboratory Manager.

Main duties / key responsibilities:

- Support the Laboratory Manager in providing a high quality Histopathology service.

- Perform histology procedures and techniques including processing, embedding, microtomy, H&E and special empirical stains

- Provide a range of digital pathology services including digital slide scanning and image analysis on multiple platforms

- Ensure the effective maintenance of equipment and appropriate levels of consumables for the histology laboratory.

- Ensure the laboratory meets H&S and HTA requirements, maintaining detailed records of all samples, particularly those of human origin, for scientific, ethical and legal reasons.

- Histological slide quality control.

- Perform a variety of automated immunohistochemical assays.

 The above lists are not exhaustive and the job holder is required to undertake such duties as may reasonably be requested within the scope of the post. All staff are required to act in a professional, co-operative and flexibly in line with the requirements of the post and the MRC.

Education / Qualifications / Training required:


- Educated to degree level or equivalent in Biomedical Science and/or NHS biomedical science training in histopathology, or an equivalent level of research experience.

Previous work experience required:


- Experience with all aspects of FFPE histology including tissue preparation and handling, microtomy, H&E staining.

- Histochemical special stains.

- Immunohistochemical staining.


- Image analysis/ use of Visiopharm/Perkin Elmer Vectra.

- Digital slide scanning.

- Use of the Hamamatsu Nanozoomer.

- Immunofluorescence.

- In situ hybridisation/ knowledge of RNAscope.

- Multiplex immunoassays.

- Automated immunostaining/use of Ventana Discovery Ultra.

- Experience of working to GLP standards.

Personal skills/behaviours/qualities:


- Enthusiasm to learn and optimise new procedures and techniques.

- Highly organised.

- Good interpersonal skills.

- Clear communicator.

- Able to work well as part of a team.

- Work well under pressure.

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.

The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

Final appointments will be subject to pre-employment screening.

This opportunity is closed to applications.