Leading science for better health

View Vacancy -- RCUK Innovation Fellowships - TOX - 655

Open Date
07/09/2017, 10:30
Close Date
10/10/2017, 23:55
MRC Toxicology Unit

The Medical Research Council Toxicology Unit, located at the University of Leicester, is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The Unit is equipped with state-of-the-art facilities and offers excellent opportunities for postdoctoral development.

Please note the MRC Toxicology Unit, located at the University of Leicester, is currently in the process of transferring to the University of Cambridge. Legal transfer will take place in March 2018; the physical relocation is expected to take place in early 2020.


UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org

MRC - 4
MRC Band 4 £30,162-£38,545 / MRC Band 3 £37,395-£50,517
Registered Clinicians receive a clinical allowance according to experience (Ranging from £1,883 - £14,341)
Fixed Term
Full Time
Until 31/03/2021

Overall Purpose

We are pleased to announce the launch of a new Post-doctoral Fellowship Training Programme suitable for scientists looking for an opportunity to broaden experience and develop cross-disciplinary skills. Six clinical/non-clinical Fellowships are available on this unique, collaborative research training programme, which will provide novel training and research opportunities in fundamental mechanistic toxicology, exposure modelling, exposomics and clinical pharmacology/drug safety.

The programme will be jointly administered by three establishments (two Fellows based at each Centre), these will be the MRC Toxicology Unit (MRC-TU Leicester), the MRC Centre for Drug Safety Science (MRC-CDSS, University of Liverpool) and the MRC-Public Health England (PHE) Centre for Environment & Health (MRC-PHE CEH, Imperial College and King’s College London). The scheme brings together combined scientific expertise of staff from the participating Institutions in toxicological, environmental and pharmacology to provide an exciting new framework for research, training and interaction with industry. Each Fellowship will be allocated to a host institution. Projects will be joint between two of the three Centres with approximately 3-6 months being spent at the partner Centre, this will ensure that Fellows benefit from the varied working environments and facilities on offer to enable the acquisition of a wide-ranging applied skills set.

On completion of a Fellowship, individuals will be highly competitive to apply for Senior Fellowships and establish independent research programmes.

Examples of possible projects include studies into toxicities associated with i) nanofibre (e.g. carbon nanotube) exposure (MRC-TU, CEH-PHE), ii) pathways that link sodium excretion, blood pressure and cardiovascular disease (CEH-PHE, MRC-TU), iii) immune check-point inhibitors (CDSS, MRC-TU), iv) alcohol liver disease (CEH-CDSS).

Working Relationships

The post holder will report directly to Professor Anne Willis but is expected to work closely with the MRC Centre for Drug Safety Science (MRC-CDSS, University of Liverpool) and the MRC-Public Health England (PHE) Centre for Environment & Health (MRC-PHE CEH, Imperial College and King’s College London). It is important to be able to work efficiently as part of a team and to collaborate effectively with colleagues.

Main Duties / Responsibilities

In discussion with Anne Willis, the post holder will be responsible for leading and managing a research project within the area of fundamental mechanistic toxicology.


  • To provide intellectual input and innovative insight required for the development of the project
  • To develop and apply a broad range of cutting-edge techniques in order to pursue the research objectives of the project
  • To participate in collaborative research, both within the Toxicology Unit and (according to project) the MRC Centre for Drug Safety Science (MRC-CDSS, University of Liverpool) and the MRC-Public Health England (PHE) Centre for Environment & Health (MRC-PHE CEH, Imperial College and King’s College London). This will include approximately 3-6 months being spent at the partner Centre.
  • To be actively engaged in the dissemination of new research results in the form of scientific papers
  • To present scientific work at seminars within the Unit and at external meetings where appropriate
  • To communicate and collaborate with others to develop the most appropriate methodologies, and to receive training in the use of relevant experimental techniques
  • To contribute towards the smooth running of the lab including the effective use of resources, and taking responsibility for the use of communal facilities
  • To contribute to the Unit’s mission in the public engagement of science


This post is of a finite duration and offers no guarantee of continued employment with the MRC.

Education / Qualifications / Training required


  • PhD in a relevant discipline (or equivalent)
  • Considerable experience of innovative molecular research

Knowledge and experience


  • Proven skills in working independently to solve experimental problems
  • Ability to establish new techniques in the laboratory
  • To have published in a peer reviewed journal


  • Experience of molecular toxicology/pharmacology

Personal skills/behaviours/qualities


  • Vision and ability to plan and manage projects over the medium term
  • Able to demonstrate leadership ability within their research
  • Drive and focus to work at highly competitive international level with full commitment to publication of data
  • Strong commitment to team work



  • Able to collaborate and provide advice to other researchers both inside and outside the Unit


*Appointment to MRC Band 3 requires significant relevant postdoctoral experience and evidence of a trajectory towards independence, including an excellent publication record.

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.

The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

Final appointments will be subject to pre-employment screening.

This opportunity is closed to applications.