View Vacancy -- Postdoctoral Scientist - Structural Studies - Dr Kiyoshi Nagai - LMB 726
The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years.
There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.
With the new laboratory the LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.
To work within the Group of Dr Kiyoshi Nagai at the Laboratory of Molecular Biology (LMB) within an ERC-funded programme (SPLICE3D) aimed at solving the structures of mammalian and yeast spliceosomes by electron cryo-microscopy.
To lead a cryo-EM project on the mammalian and yeast spliceosome within an overall programme of ERC-funded research (SPLICE3D).
To play a major role in the work of the Research Group, through experimental work, introduction of new ideas, dissemination of research results, support and training of others.
To be a focus of expertise on mammalian and yeast cell engineering and cryo-EM studies of mammalian spliceosome.
• Under the general leadership of the Group Leader, Dr Kiyoshi Nagai, to be responsible for all aspects of the research projects, including defining the direction of the work, conducting the research, analysing the data, preparing the work for publication and disseminating the results at meetings.
• To contribute to Laboratory-wide discussions on developments within the Laboratory, particularly in the use of new techniques or new equipment.
• To identify, develop and apply a broad range of techniques to pursue the research objectives including by working in collaboration with others to achieve joint research projects.
• To keep up to date with developments in the field, proposing or implementing changes of direction as necessary.
• To prepare the research for publication.
• To present your work at seminars within the Laboratory and at external meetings.
• To train Students, Postdoctoral Scientists and others and undertake the line management of Group members where appropriate.
• To contribute to the MRC’s engagement with the public and in the translation of research findings into improvements in health care.
Within the overall direction of the programme, the Group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three year lifespan.
To plan your own work and objectives on a 12 month basis and manage your experimental work within the project along with your Supervisor.
To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.
To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.
To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.
To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.
To enhance your research and generic skills through a tailored development programme.
You will report to Dr Kiyoshi Nagai and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.
This is a three-year training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including:
• MRC training courses.
• External training and personal development courses.
• One-to-one training with your Supervisor and other Scientists.
You will commit to undertaking the following:
• Developing and following a personal development plan.
• Attending training courses.
• Identifying additional training which will support you to develop your career.
The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC.
These should include a PhD or due to complete a PhD within 6 months in a relevant field of molecular and structural biology.
Technical skills and expertise:
• Experience of and ability to perform techniques relevant to the project. Particularly useful would be experience of X-ray crystallography, electron cryo-microscopy or protein/RNA chemistry.
• Previous experience in cloning and protein purification.
Desirable: Extensive skills in purification of large complexes from yeast and/or tissue culture cells is desirable.
Track record of research:
• This will include achievements, and contributions to published papers.
• Good solid publications from PhD work to which the host holder has made significant contribution both intellectually and technically.
Desirable: Good understanding of protein and RNA structures through previous crystallographic or cryo-EM studies.
Other relevant evidence of:
• Ability to communicate.
• Working with others.
The abilities to learn new techniques proactively from other postdoctoral scientists as well as to work as a team member are essential.
Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.
This opportunity is closed to applications.