The LMS is a world-class research laboratory where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. Funded by the MRC as part of UK Research and Innovation, the LMS has a collaborative working culture and new state-of-the-art building based in the heart of West London in the Hammersmith Hospital Campus (W12).
The LMS aims to deliver transdisciplinary team science, in synergistic interaction with Imperial College and the wider national research environment. Part of achieving this, is to recruit new talent and support postdoctoral scientists to become world leaders in their area of science.
Overall purpose:
To advance our understanding of genome architecture and epigenetic regulation using cutting-edge single-cell and multi-omics technologies.
About the Laboratory:
The Vaquerizas Laboratory at the MRC Laboratory of Medical Sciences is internationally recognised for pioneering research in 3D genome organisation, epigenomics and single-cell multiomics (e.g., Hug et al., Cell 2017; Galan et al., Nature Genetics 2020; Ing-Simmons et al., Nature Genetics 2021). Our most recent work focuses on understanding key processes in human and mouse development, male infertility, and epitranscriptomics, using cutting-edge genomic and transcriptomic technologies.
We take a multidisciplinary approach, integrating molecular biology, genomics, computational biology, and systems-level analyses to address fundamental biological questions. The lab fosters a collaborative and supportive research environment, encouraging independent scientific growth and offering access to state-of-the-art core facilities and comprehensive training opportunities.
Thematic Research Interests:
About the Role:
This position focuses on computational analysis and method development for large-scale multiomics datasets, particularly those derived from single-cell, spatial, and 3D genome experiments. The successful candidate will work closely with experimental collaborators, contribute to the development of reproducible analytical pipelines, and explore new computational frameworks for integrating diverse data types. There will be opportunities to lead independent projects and co-supervise students.
Main duties / Key responsibilities:
Additional information:
These are MRC Postdoctoral Research Scientist positions designed to support postdoctoral training and help establish successful research careers. During the fellowship, we are committed to providing mentorship for career development, including support for communication skills, grant writing, and scientific leadership.
We offer a highly attractive benefits package, including a competitive salary and pension scheme, as well as access to world-class research facilities and training programmes.
Education / Qualifications / Training required (will be assessed from application form):
Essential:
Previous work experience required (will be assessed from application form and at interview):
Desirable:
Knowledge and experience (will be assessed from application form and at interview):
Personal skills / Behaviours / Qualities (will be assessed at the interview):
Applicants should submit one CV, a brief cover letter describing how the candidate fits the person specifications and motivation for the post and names and contacts of two scientific references. Please quote reference number LMS 2664.
Please note that applications may be reviewed by both LMS and Imperial staff
The MRC is a unique working environment where scientific researchers and professional support staff can actively partake in world class innovation and collaboration opportunities and their skills and knowledge through accessing a wide catalogue of training & development, including professional registration with the Science Council.
In addition, MRC (part of UKRI) provides its community of employees access to a whole host of useful benefits, including a defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more - Benefits Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We warmly invite people from diverse backgrounds and heritage, including people who identify as having a disability, to apply for a role that excites them. As "Disability Confident" employers, any candidate who opts into the scheme and best meets the essential criteria, will be shortlisted for interview.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.
This opportunity is closed to applications.
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