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View Vacancy -- Histology Research Officer - TOX - 666

Open Date
02/10/2017, 14:00
Close Date
18/10/2017, 23:55
MRC Toxicology Unit

The Medical Research Council Toxicology Unit, located at the University of Leicester, is an internationally renowned institution focussed on the delivery of field-changing mechanistic insights into toxicology and disease. The histology facility houses state-of-the art facilities for research histological methods and provides specialist histology support to our research groups.

We are now looking to appoint an experienced Histology Research Officer to join the histology facility.

Please note the Toxicology Unit is in the process of transferring to the University of Cambridge. Legal transfer will take place in March 2018 but the Unit will remain located at Leicester until 2020.

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

MRC - 5
£21,951 - £25,718
Full Time

Working relationships:


  • The post holder reports directly to the Histopathology Laboratory Manager.


Main duties / key responsibilities:


  • Support the Laboratory Manager in providing a high quality Histopathology service and manage the service in their absence
  • Perform histology procedures and techniques including processing, embedding, microtomy, H&E and special empirical stains
  • Provide a range of digital pathology services including digital slide scanning and image analysis on multiple platforms
  • Ensure the effective maintenance of equipment and appropriate levels of consumables for the histology laboratory
  • Ensure the laboratory meets H&S and HTA requirements, maintaining detailed records of all samples, particularly those of human origin, for scientific, ethical and legal reasons
  • Provide advice to scientific staff regarding the most appropriate histopathological approach
  • Histological slide quality control
  • Train and supervise any work undertaken in the histopathology laboratory by junior scientific staff and ensure the facility is maintained to a high standard
  • The above lists are not exhaustive and the job holder is required to undertake such duties as may reasonably be requested within the scope of the post. All staff are required to act in a professional, co-operative and flexibly in line with the requirements of the post and the MRC.


Person specification:


Education / Qualifications / Training required:




Educated to degree level or equivalent in Biomedical Science, and/or extensive experience

NHS biomedical science training in histopathology, or an equivalent level of research experience


Previous work experience required:



  • Proficient in all aspects of FFPE histology including tissue preparation and handling, microtomy, H&E staining
  • Ability to troubleshoot problem samples
  • Cryostat sectioning
  • Histochemical special stains
  • Experience of working to HTA guidelines
  • Digital slide scanning




  • Image analysis/ use of Visiopharm/Perkin Elmer VectraImmunohistochemical staining
  • Database management
  • Use of the Hamamatsu Nanozoomer
  • Immunofluorescence
  • In situ hybridisation/ knowledge of RNAscope
  • Multiplex immunoassays
  • Automated immunostaining/use of Ventana Discovery Ultra
  • Experience of working to GLP standards
  • Experience of supervising and training junior staff


Personal skills/behaviours/qualities:



  • Enthusiasm to learn and optimise new procedures and techniques
  • Highly organised
  • Good interpersonal skills
  • Clear communicator
  • Able to work well as part of a team
  • Work well under pressure

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.

The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

Final appointments will be subject to pre-employment screening.

This opportunity is closed to applications.