View Vacancy -- Investigator Scientist - Neurobiology - Dr Greg Jefferis - LMB 2365

Open Date
28/02/2024, 09:00
Close Date
03/04/2024, 23:55
MRC Laboratory of Medical Sciences and MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

The LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

MRC - 4
£41,843 - £43,962 per annum
Fixed Term
Full Time
2 years

Overall purpose: 

To work within the group of Dr Greg Jefferis at the LMB in collaboration with Dr Joseph Collin at AstraZeneca on a project aimed at understanding gene programs driving neuronal diversity and wiring specificity emerging from the connectome. The successful candidate will begin work on a recently acquired scRNAseq dataset of the developing fly nerve cord. This has unprecedented cellular coverage (~ 10x oversampling), which will be further expanded in the course of the project. Pilot analysis has already revealed a highly structured organisation of neurons in the dataset according to their birth origin, providing a direct link to the ventral nerve cord connectome ( This offers the possibility to take a divide and conquer approach to match two very complex but foundational Omics datasets. Linking the developmental transcriptome and  connectome will lay the foundations for molecular connectomics, with long-term implications for the study of circuit function, development and disease.

Main duties:

●    Under the general leadership of the Group Leader, to be responsible for all aspects of the research projects, including defining the direction of the work, conducting the research, analysing the data, preparing the work for publication and disseminating the results at meetings.

●    Develop computational tools to integrate scRNAseq datasets from different developmental timepoints.

●    Model cell type identities along developmental trajectories for individual stem cells, integrating precise knowledge of cell type composition derived from the connectome.

●    Participate in collecting new scRNAseq data at AZ (Cambridge) to a) use molecular barcoding  to reveal birth timing within the transcriptomic data structure and b) scale studies from the nerve cord (~25,000 neurons) to the brain (~135,000 neurons).

●    Interact with the AZ team in Gothenburg (Sweden) led by Joseph Collin, which may include site visits and short stays for training and analysis purposes.

●    To contribute to laboratory-wide discussions on developments within the laboratory, particularly in the use of new techniques or new equipment.

●    To identify, develop and apply a broad range of techniques to pursue the research objectives including by working in collaboration with others to achieve joint research projects.

●    To keep up to date with developments in the field, proposing or implementing changes of direction as necessary.

●    To prepare the research for publication.

●    To present your work at seminars within the laboratory and at external meetings.

●    To train students, Postdoctoral Scientists and others and undertake the line management of group members where appropriate.

●    To contribute to the MRC’s engagement with the public and in the translation of research findings into improvements in health care.

Key responsibilities:

The key responsibility is to undertake cutting-edge research, aimed at key questions within the remit of the research group.  You will be expected to provide the intellectual energy and independent thinking necessary to deliver the research and to play a major role in shaping the overall aims and success of the group.

While some advice will be available from others in the laboratory, you will be expected to have the skill and understanding to be able to act independently in solving problems, many of which may require novel approaches.  This will require the integration of different activities to ensure the successful delivery of the research projects.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches. 

To interact effectively with a wide range of staff, students and others to ensure the smooth running of the research group. This will include setting an example in the effective use of resources, training others in methods and use of equipment and taking responsibility for the use of communal facilities. 

To potentially take on specific responsibilities for managing equipment.

To write scientific papers and to present at internal meetings and at conferences.  

To ensure the research is conducted in accordance with good practice and in compliance with local policies and legal requirements.

To recognise opportunities for the creation of intellectual property and to cooperate in patent protection and in exploitation.

To identify new equipment which will assist the group programme and to present argued cases for new purchases.

To identify opportunities for additional funding and to apply for external grants where appropriate.

Where line management responsibilities are undertaken, these responsibilities, including staff development and performance management, should be applied in accordance with the MRC’s policies and procedures. Training will be provided if required.

Working relationships: 

You will report to Dr Greg Jefferis and will liaise with senior scientists, including Dr Sebastian Cachero, and students in your group, across the LMB and with external collaborators at AstraZeneca and the CNR, Milan. 

Academic qualifications and experience: 

PhD in a relevant subject or a Master's degree in a relevant subject and significant research experience in bioinformatics.

Significant research experience in Bioinformatics, Computer Science, AI or relevant fields. 

Technical skills and expertise:

Experience of and proven ability to perform techniques relevant to the project, and knowledge of the field.  Particularly useful would be experience of:

  • Coding in R and/or Python.
  • Experience with at least one of:
    • Single-cell transcriptomics data analysis
    • Machine learning
  • Experience with software/open science best practices (desirable).
  • Neuroscience/development/Drosophila genetics/dissections/molecular biology (not essential)

Track record of research:

This will include achievements, and significant contributions to published papers.

Other relevant evidence of: 

•    Commitment.
•    Originality.
•    Ability to communicate.
•    Working with others.

Please also provide a link to your github in your cover letter. 

We will start reviewing candidates as soon as we receive their applications.

Corporate/Local responsibilities & requirements

You must at all times carry out your responsibilities with due regard to the UKRI: 
•    Code of Conduct
•    Equality, Diversity and Inclusion policy
•    Health and Safety policy
•    Data Protection policy

Job descriptions should be reviewed on a regular basis and at the annual appraisal.  Any changes should be made and agreed between you and your manager.

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI.  

The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.

We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.  The role holder will be required to have the appropriate level of security screening/vetting required for the role.  UKRI reserves the right to run or re-run security clearance as required during the course of employment.

This opportunity is closed to applications.