View Vacancy -- Postdoctoral Scientist - Neurobiology - Dr Michel Goedert - LMB 2752

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

The LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation

Overall purpose: 

To work in the group of Dr Michel Goedert from the Neurobiology Division of the MRC Laboratory of Molecular Biology (LMB), as part of a programme aimed at understanding Molecular Mechanisms of Neurodegeneration. Specifically, to undertake research to investigate mechanisms in cells and animals that cause the formation of amyloid filaments with structures like those from human brains. This work will be done in close collaboration with the group of Dr Sjors Scheres from the Structural Studies Division of the LMB.

The assembly of the proteins tau, alpha-synuclein and beta-amyloid into abnormal amyloid filaments is central to the development of most cases of human neurodegenerative disease. Since 2017, we have been using electron cryo-microscopy (cryo-EM) to determine the structures of these filaments from human brains. We have shown that specific filament folds define distinct diseases, with differences in filament structures being between some diseases, but not between individuals with a given disease. To understand mechanisms of disease, one must be able to form filaments in experimental settings that have the same structures as those from human brains in vitro, in cells and in animals. This has so far only been achieved for Alzheimer tau filaments. This position is to develop methods for producing additional tau folds and to use cryo-EM and/or electron cryo-tomography (cryo-ET) to further analyse tau folds. Recombinant mutant tau proteins, mixed primary cortical mouse cultures and differentiated human iPSCs will be used, as will amyloid seeds prepared from diseased human brains. Animals will be transgenic mice that express tau in brain cells.    

Main duties:

•    To undertake research aimed at understanding mechanisms of neurodegeneration.
•    To identify, develop and apply a broad range of techniques to pursue the research objectives.
•    To present scientific work at seminars within the laboratory and at external meetings.
•    To contribute to laboratory-wide discussions on developments within the field. 
•    To draft scientific papers and contribute to the overall preparation of research for publication.
•    To contribute to the LMB’s mission in the public engagement of science and the translation of research findings into improvements in health care.
•    To assist in the training of PhD students and other members of the LMB.

Key responsibilities:

Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan. 

To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your supervisor.

To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.

To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.

To enhance your research and generic skills through a tailored development programme. 

Working relationships: 

You will report to Drs Michel Goedert and Sjors Scheres and you will interact and collaborate with other Postdoctoral Scientists, Research Support staff and Students, not only in your group, but also across the LMB and with external groups as necessary.

Additional information:

This is a three-year training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including:
•    MRC training courses.
•    External training and personal development courses.
•    One-to-one training with your supervisor and other Scientists.

You will commit to undertaking the following:
•    Developing and following a personal development plan.
•    Attending training courses.
•    Identifying additional training which will support you to develop your career.

Academic qualifications: 

These should include a PhD in a relevant subject or due to complete a PhD within 6 months.

Technical skills and expertise:

Essential
The successful candidate will have experience in the generation of experimental models of amyloid formation and/or cryo-EM/cryo-ET.

Experience in standard molecular biology techniques of cloning and cell culture or protein purification.

Desirable
Experience in pluripotent stem cell conversion or cryo EM/cryo-ET

Track record of research:

This will include contributions to published papers.

Other relevant evidence of: 

•    Commitment.
•    Originality.
•    Ability to communicate.
•    Working with others.

Application information: 

Applicants are required to submit a full CV and cover letter.

It is anticipated interviews will take place week commencing 19 January 2026.

You must at all times carry out your responsibilities with due regard to the UKRI: 
•    Code of Conduct
•    Equality, Diversity and Inclusion policy
•    Health and Safety policy
•    Data Protection policy

Job descriptions should be reviewed on a regular basis and at the annual appraisal.  Any changes should be made and agreed between you and your manager.

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI.  

The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.