View Vacancy -- Investigator Scientist (Maternity Cover) - Cell Biology - Dr Mario de Bono - LMB 1013
The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years.
There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.
The LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.
To work within the Group of Dr Mario de Bono at the Laboratory of Molecular Biology (LMB) to analyse next generation sequencing data of whole genomes or mRNA so as to analyse mutations of animals and transcriptomes of neuronal cell types. This is within an overall programme that seeks to understand how nervous systems control behaviour and physiology.
To play a major role in the work of the Research Group, through the analysis of accumulated sequence data and also provide support to other LMB groups seeking to use next generation sequencing approaches. LMB includes a wide variety of research programmes offering different opportunities for collaboration that bring with them new kinds of datasets.
To work with existing software pipelines constructed using Python and R and to set up user-friendly online interfaces that enable scientists who are not bioinformaticians to analyse data.
• Under the general leadership of the Group Leader, to be responsible for setting up, developing pipelines to analyse next generation sequencing data, preparing the work for publication and disseminating the results at meetings.
• To present scientific work at seminars within the Laboratory and at external meetings.
• To contribute to Laboratory-wide discussions on developments within the field.
• Where appropriate, to help draft scientific papers, and contribute to the overall preparation of research for publication.
• To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.
• To assist in the training of PhD students and other members of the LMB.
To undertake analysis of next generation sequencing data, aimed at key questions within the remit of the Research Group. You will be expected to provide the intellectual energy and independent thinking necessary to deliver the research and to play a major role in shaping the overall aims and success of the Group.
While some advice will be available from others in the Laboratory, you will be expected to have the skill and understanding to be able to act independently in solving problems, many of which may require novel approaches. This will require the integration of different activities to ensure the successful delivery of the research projects.
To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.
To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.
To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.
You will report to Dr Mario de Bono and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.
Academic qualifications and experience:
PhD in a relevant subject.
Technical skills and expertise:
Experience of and ability to perform techniques relevant to the project. Particularly useful would be experience of analysing next generation sequencing data – genomes and transcriptomes.
Experience using R or Python. Experience working with Linux/UNIX command line interfaces.
Track record of research:
This will include achievements, and significant contributions to published papers.
Other relevant evidence of:
• Ability to communicate.
• Working with others.
Use of industry standard software to analyse genome and transcriptome data is essential for this role as is experience collaborating with experimental biologists doing wet work.
Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.
This opportunity is closed to applications.