View Vacancy -- Junior Data Wrangler - MGU 1064

Open Date
03/04/2019, 16:40
Close Date
30/04/2019, 23:55
MRC Mammalian Genetics Unit
MRC Harwell Institute is an international biological research centre at the forefront of the use of mammalian models to study genetics and human diseases. Located on the Harwell Campus, just south of Oxford, it is nestled amongst a vibrant community of leading science organisations. We aim to advance medicine through cutting-edge research into the genetic basis of disease. Our research programs span an entire lifetime, from embryonic development to diseases of ageing. There are over 300 staff at the Institute made up of research scientists, technicians, animal carers, and business support personnel.
UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

MRC - 5
Harwell Campus, Oxfordshire
£29,989 to £32,838 inclusive of a £6,500 Bioinformatics Allowance
£6,500 Bioinformatics Allowance
Fixed Term
Technical & Scientific Professionals
Full Time
Fixed Term until 30th September 2020

Overall purpose:

We are seeking one highly motivated and enthusiastic Data Wrangler/Bioinformatician to join the International Mouse Phenotyping Consortium’s (IMPC) Data Coordination Centre (DCC). You will be part of a team of 4 Data Wranglers. Together the Wranglers work with the 11 data generating centres to ensure the highly multi-dimensional data generated from this international project is robust and reproducible. As a Junior Data Wrangler, you will assist the Data Wranglers by applying approaches and methods, that they develop for quality control and downstream data analysis using informatics and statistical techniques.

The goal of the IMPC is to discover functional insight for every gene by generating and systematically phenotyping 20,000 knockout mouse strains. One of the most important tools at our scientific disposal in understanding mammalian gene function is the laboratory mouse. The fundamental genetic similarity between mice and humans allows researchers to infer a human gene's function based on studies with laboratory mice. One powerful technique is to turn off, or "knockout", the activity of a mouse gene to assess what biological systems are impacted. This gives insights to how a similar gene in humans may contribute to disease when its activity is altered.

The DCC delivers a wide range of advice/help/troubleshooting for the IMPC member centres and provides the initial entry point of data collected by these centres. Over the last five years the DCC has received over 70 million data points into the custom-made database. The DCC team comprises of developers, data wranglers and researchers who come together to ensure the data is robust and disseminated to the wider community.

Main duties / key responsibilities:

  • To assist the Data Wranglers as an interface between the DCC and the IMPC member centres
  • To provide support to the IMPC member centres with all aspects of data uploads, data corrections and troubleshooting
  • Communicate effectively using a variety of platforms, such as email, teleconferences, attending and presenting at international meetings and conferences    
  • To assist in the evaluation of the success of particular IMPC Procedures through analyses and interpretation of key data
  • To assist in the follow-up of IMPC-wide and centre-specific data issues
  • To assist in the effective communication of the projects to the scientific community and stakeholders within the antibiotic resistance area
  • To keep key people informed on progress and developments connected with delivery of a particular task
    • To build and maintain effective communications and relationships internally and externally
    • To undertake any other duties appropriate to the post as delegated by the Data Wrangles or DCC team and managers.

Working relationships

You will be part of the BioComputing Team.


Education / Qualifications / Training required:

Qualifications and Training:


  • A strong life sciences or computational degree

Knowledge and experience:


  • Some experience in bioinformatics techniques, data management and / or data curation
    • Familiarity with relational databases
    • Knowledge or interest in learning basic programming
    • Background in mathematical or scientific field
    • Knowledge of mouse phenotyping data
    • Experience of data presentation
    • Experience of presenting at workshops and meetings


Personal skills/behaviours/qualities:

  • Flexible and adaptable team worker
  • Excellent organisational and prioritisation skills
  • Capable of working under pressure at times to meet deadlines
    • Good written and oral communication skills including ability to present complex information in a concise and clear manner to people from different backgrounds
    • Strong interpersonal skills with evidence of having developed and maintained effective working relationships

Additional information:

The MRC Harwell Institute specialises in mouse genetics research, from the earliest stages of development to diseases of ageing. We are very keen to push our research towards translational studies in humans, and collaborate with clinical and medical professionals for many of our research programmes.

Our large-scale functional genomics projects generate vast amounts of data. These massive datasets need to be integrated, analysed and compared in order to make sense of our findings and present them in a form that can be used by both our own research groups and the wider scientific community. This effort is led by Data Wranglers in the BioComputing group, who work with the researchers and members of the Statistical Genomics group, to ensure that all findings displayed are statistically significant, standardised and quality checked. Software developers within the BioComputing group work closely with those collecting the data to constantly improve and update our systems for data collection, analysis and dissemination.

The BioComputing group also performs research on the analysis of NGS and transcriptomics data and 3D systems imaging.

More information about MRC Harwell Institute can be found at

Informal expressions of interest in this post can be sent to Dr Ann-Marie Mallon (

Other benefits also include a flexible pay and reward policy, excellent holiday entitlement, MRC average salary pension scheme.

Some international travel may be required for this role.

The closing date for applications is: 30th April 2019.

Interviews will be on or around: 9th May 2019

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.

We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.

This opportunity is closed to applications.