View Vacancy -- MRC Post Doctoral Research Scientist LMS 1073

Open Date
17/04/2019, 15:00
Close Date
21/05/2019, 23:55
MRC London Institute of Medical Science

The London Institute of Medical Sciences (LMS) at Hammersmith

Hospital is the third directly funded MRC research institute and

enjoys close links with its partners at Imperial College and at the

Imperial College Healthcare NHS Trust. The LMS research

focuses on strengthening the basic science underpinning our

understanding of human diseases and the translation of such

high quality research into a clinical setting.

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

MRC - 4
£35,859 - £38,700 per annum inclusive of London allowances*
Fixed Term
Technical & Scientific Professionals
Full Time
3 Years

Overall purpose:

Research in the Drug Transport and Tumour Metabolism lab, headed by Dr. Louise Fets, focuses on understanding the role played by plasma membrane transporters in the uptake of drugs into cells. To date, the specific transporters required for cell uptake have only been identified for a handful of drugs, and the lack of understanding of drug entry into cells could partially explain the failure of many compounds in clinical trials. Our aim is to explore how differential expression of transporters in cancer can not only influence the metabolism of the tumour, but whether this can also define its drug sensitivity profile.

To answer these questions, we use a range of techniques including cell and molecular biology, CRISPR screening, metabolomics, proteomics and bioinformatics.

Job Summary:

The successful candidate will be a key member of the Drug Transport and Tumour Metabolism group, and will enjoy a high level of scientific responsibility. They will work in a focussed and organised manner to produce independent and original research within the group, deliver the scientific aims of the project and aid in the submission of publications to refereed journals. They will also help with supervising students and contribute to the smooth running of the research group.        

Main Responsibilities:

  • To plan, carry out, and analyse research in accordance with the agreed project aims.
  • To attend all lab and related research meetings, and to present work when required.
  • To attend and contribute to journal clubs and seminar presentations.
  • To keep up to date with the scientific literature and technical advances relevant to the project.
  • To present data at national and international meetings (where and when appropriate).
  • To interact and collaborate with researchers in related projects.
  • To take an active part in the academic activities of the LMS.
  • To write up work for publication in peer-reviewed journals.
  • To form good working relationships with other members of the group, as well as internal and external collaborators.
  • To assist others and co-supervise students when required.
  • To contribute to the development and maintenance of the group’s experimental infrastructure as appropriate.
  • To help with the daily running of the lab by assisting with general lab duties as required.

This is an MRC Postdoctoral Scientist position providing training and development supporting post-doctoral scientists in early or changed career paths helping establish them as successful research scientists in their chosen field.

Applicants must have a PhD or equivalent in a relevant life sciences or biomedical discipline and extensive experience in cell culture and molecular biology techniques. An excellent track record of independent research is also essential. Expertise in metabolism/metabolomics, cancer biology and/or bioinformatics would be an advantage. The successful candidate must also have the ability to develop and apply new concepts, have a creative approach to problem solving, and be able to write clearly and succinctly for publication.

Education / Qualifications / Training required:


  • PhD (or equivalent experience) in a relevant life sciences, biomedical or related discipline

Previous work experience required:


  • Extensive experience in cell culture
  • Extensive experience in molecular biology techniques

Knowledge and experience:


  • A keen interest in metabolism and pharmacology
  • An excellent track record of independent research
  • Excellent written and verbal communication skills, ability to write clearly and succinctly for publication

*Salary quoted is inclusive of London weighting. Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year.

Applicants should submit CV with a brief cover letter describing how the candidate fits the person specifications and motivation for the post and names and contacts of two scientific references.

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.

We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.

This opportunity is closed to applications.