View Vacancy -- Postdoctoral Scientist - Structural Studies - Dr Chris Tate - LMB 1307

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies.  The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease.  We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology.  However, scientific collaboration between the different Divisions is extensive.  Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

The LMB provides an unsurpassed environment for both new and established researchers.  Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

Overall purpose:

To work within the Group of Dr Tate at the MRC Laboratory of Molecular Biology (LMB).

A biochemist is needed to study the physical, chemical form, and structure of chemical substances involved in diseases of the brain and heart.

To play a major role in the work of the Research Groups, through the conduct of research, introduction of new ideas, dissemination of research results, support and training of others.

The specific focus of the position will be to develop cryo-EM technology to study structural changes in G-Protein Coupled Receptor (GPCRs) during G protein coupling.

Main duties:

•    Under the general leadership of the Group Leader, to be responsible for all aspects of the research projects, including defining the direction of the work, conducting the research, analysing the data, preparing the work for publication and disseminating the results at meetings.

•    To contribute to Laboratory-wide discussions on developments within the Laboratory, particularly in the use of new techniques or new equipment.

•    To identify, develop and apply a broad range of techniques to pursue the research objectives including by working in collaboration with others to achieve joint research projects.

•    To keep up to date with developments in the field, proposing or implementing changes of direction as necessary.

•    To draft scientific papers, and contribute to the overall preparation of research for publication.

•    To present your work at seminars within the Laboratory and at external meetings.

•    To assist in the training of PhD Students and other members of the LMB.

•    To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.

Key responsibilities:

Within the overall direction of the programme, the Group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a 3 year lifespan.

To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor.

To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.

To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.

To enhance your research and generic skills through a tailored development programme.

Working relationships:

You will report to Dr Tate and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.

Additional information:

This is a 3-year training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including:
•    MRC training courses.
•    External training and personal development courses.
•    One-to-one training with your Supervisor and other Scientists.

You will commit to undertaking the following:
•    Developing and following a personal development plan.
•    Attending training courses.
•    Identifying additional training which will support you to develop your career.


The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC.

Academic qualifications and experience:

Essential: PhD in structure determination of GPCRs or in a relevant subject or due to complete PhD within 6 months.

Desirable: Degree in mathematics and/or physics.

Technical skills and expertise:

Experience of and proven ability in structure determination of GPCRs using either X-ray crystallography or cryo-EM. Particularly useful would be skills in expression and purification of GPCRs are also considered as assets.

Track record of research:

This will include achievements, and significant contributions to published papers.

Other relevant evidence of:

•    Commitment.
•    Originality.
•    Ability to communicate.
•    Working with others.