View Vacancy -- Bioinformatician (Research Support) - PNAC - Dr Andrew McKenzie - LMB 1538
There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.
The LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.
To work as a Bioinformatician within the research group of Dr Andrew McKenzie in the PNAC Division at the MRC Laboratory of Molecular Biology (LMB) investigating immune reactions to disease. In particular to design and analyse next generation sequencing projects that use single cell RNA sequencing, ATAC-Seq, ChIP-seq, three-dimensional chromosome conformation (e.g. Hi-C), CRISPR-Cas screens, etc to investigate the development and function of immune cells.
• Under the general leadership of the Group Leader, to be responsible for setting up, developing pipelines to analyse next gen sequencing data and preparing the work for publication.
• To present your work at seminars within the Laboratory and at external meetings.
• To contribute to Laboratory-wide discussions on developments within the Laboratory, particularly in the use of new techniques or new equipment.
• To keep up to date with developments in the field, proposing or implementing changes of direction as necessary.
• To prepare the research for publication.
• To work in collaboration with others to achieve joint research projects.
• To train Students, Postdoctoral Scientists and others and undertake the line management of Group members where appropriate.
• To contribute to the MRC’s engagement with the public and in the translation of research findings into improvements in health care.
The key responsibility is to undertake bioinformatics analysis aimed at key questions within the remit of the Research Group. You will be expected to contribute the intellectual energy and independent thinking necessary to deliver the research and to play a role in shaping the overall aims and success of the group.
While some advice will be available from others in the Laboratory, you will be expected to have the skill and understanding to be able to act independently in solving problems, many of which may require novel approaches. This will require the integration of different activities to ensure the successful delivery of the research projects.
To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches. To set up pipelines enabling non-specialists to analyse data online.
To interact effectively with a wide range of Staff, Students and others to ensure the smooth running of the Research Group. This will include setting an example in the effective use of resources, training others in methods and use of equipment and taking responsibility for the use of communal facilities.
To potentially take on specific responsibilities for managing equipment.
To write scientific papers and to present at internal meetings and at conferences.
To ensure the research is conducted in accordance with good practice and in compliance with local policies and legal requirements.
To recognise opportunities for the creation of intellectual property and to cooperate in patent protection and in exploitation.
To identify new equipment which will assist the Group programme and to present argued cases for new purchases.
To identify opportunities for additional funding and to apply for external grants where appropriate.
Where line management responsibilities are undertaken, these responsibilities, including staff development and performance management, should be applied in accordance with the MRC’s policies and procedures. Training will be provided if required.
You will report to Dr Andrew McKenzie and will liaise with other Research Support Staff, Postdoctoral Scientists and Students, not only in your Group, but also across the LMB and with external collaborators.
This post is available as a full-time position, however part time working will also be considered at a minimum of 3 days per week.
The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC.
Academic qualifications and experience:
• 1st degree or Masters in a relevant subject AND equivalent experience in a bioinformatics role OR PhD degree in relevant subject
• Experience using UNIX/Linux based systems and fluency in scripting with R, Perl or Python.
Desirable: Experience in biological research. Working knowledge of statistics, e.g using Matlab, Mathematica, R etc.
Specific Research Skills
• Use of industry standard software to analyse genome and transcriptome data.
• Experience of collaborating with experimental biologists doing wet work.
• Data mining using publicly available databases; setting up and curating in house relational databases.
• Skills in programming in multiple languages and in statistics.
• Able to help people design sequencing experiments.
• A working knowledge of wet-lab pipelines for generating NGS data, i.e. 10X scRNA-seq, NGS library preparation, etc.
Creativity and Initiative
• Has developed new techniques/methodologies that have added value to scientific work.
• Experience/results in cutting edge research.
Desirable: Have independent scientific recognition.
Essential: Proven skills in working independently to solve problems in data analysis.
Verbal and written communication skills
Essential: Experience in presenting scientific work, both written and orally.
Desirable: Good quality publications in bioinformatics. Experience of teaching in informatics, or a related subject.
Personal skills / behaviours / qualities
• Excellent standards of research conduct.
• Strong team player.
• Capable of taking independent decisions.
Track record of research:
This will include achievements, and significant contributions to published papers.
Other relevant evidence of:
• Ability to communicate.
• Working with others.
Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.
We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.