View Vacancy -- Postdoctoral Scientist - Neurobiology - Dr William Schafer - LMB 321

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies.  The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease.  We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology.  However, scientific collaboration between the different Divisions is extensive.  Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

With the new laboratory the LMB provides an unsurpassed environment for both new and established researchers.  Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

Overall purpose:

To work within the Group of William Schafer at the Laboratory of Molecular Biology (LMB), within a programme aimed at understanding the molecular and cellular mechanisms of behaviour. Specifically to undertake research to investigate gene products that play important and conserved functions in the detection of aversive mechanical and thermal stimuli and the control of behavioural states. Key approaches will be to record from touch and pain-sensing neurons of nematodes by electrophysiology and/or optical imaging and determine how these molecules affect sensory transduction.

Main duties:

•  To undertake research aimed at discovering mechanisms of arousal and pain modulation
•  To identify, develop and apply a broad range of techniques to pursue the research objectives.
•  To present scientific work at seminars within the Laboratory and at external meetings.
•  To contribute to Laboratory-wide discussions on developments within the field.
•  To draft scientific papers, and contribute to the overall preparation of research for publication.
•  To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.
•  To assist in the training of PhD Students and other members of the LMB.

Key Responsibilities:

Within the overall direction of the programme, the Group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a 3 year lifespan.

To plan your own work and objectives on a 12 month basis and manage your experimental work within the project along with your Supervisor.

To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.

To ensure the research is carried out in accordance with good practice and in compliance with local polices and legal requirements.

To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.
To enhance your research and generic skills through a tailored development programme.

Working relationships:

You will report to Dr William Schafer and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.

Additional information:

This is a three-year training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including:

•  MRC training courses.
•  External training and personal development courses.
•  One-to-one training with your Supervisor and other Scientists.

You will commit to undertaking the following:
•  Developing and following a personal development plan.
•  Attending training courses.
•  Identifying additional training, which will support you to develop your career.

Education / Qualifications / Training required:

Essential: PhD in a biological subject or due to complete doctoral studies within 6 months of applying (in a biological subject).

Previous work experience required:

Essential:
•  Experience with electrophysiological recording from C. elegans neurons.
•  Experience with fluorescence microscopy of nematodes.

Knowledge and experience:

Creativity and Initiative
Essential:
•  Ability to carry out experimental programme.
•  Demonstrated ability to develop novel experimental approaches e.g. new methodologies and techniques.
•  Ability to contribute ideas and provide support to other projects in the Groups.

Desirable: Has developed new techniques/methodologies which have added value to scientific work.

Independent working
Essential: Proven skills in working independently to solve experimental problems.

Verbal and written communication skills
Essential:
•  Experience in presenting scientific work, both written and orally.
•  Has made contributions to scientific papers.
•  Strong publication record demonstrating research productivity.

Mentoring
Desirable: Has experience of training others "on the job".

Collaborations/ Influencing Skills
Essential: Has strong skills and experience in working collaboratively as a member of a team.

Personal skills/behaviours/qualities:

Essential: Motivated individual with a strong desire for self and team development.