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View Vacancy -- Senior Investigator Scientist / Investigator Scientist - Structural Studies - Dr Julian Gough - LMB 477

Open Date
28/02/2017 09:55
Close Date
29/03/2017 23:55
MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies.  The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease.  We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology.  However, scientific collaboration between the different Divisions is extensive.  Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

With the new laboratory the LMB provides an unsurpassed environment for both new and established researchers.  Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

MRC - 3
Cambridge
£30,162 - £43,956
Fixed Term
Science
Full Time
5 Years

Senior Investigator Scientist


Overall purpose: 

To lead on a range of projects within the Group of Prof Julian Gough at the Laboratory of Molecular Biology (LMB), as part of an overall programme on protein domains and genomics.
There is established research in the group on protein structure domains (SUPERFAMILY), protein disorder (D2P2), protein function and phenotype (dcGO) and other areas such as genetic variation (FATHMM). This project is to bring together our previous research in these areas and unite it into a coherent system for conducting genomic research, and to apply that to biological problems.
To inspire ideas for research for the next 3-5 years in the context of the work of the Division.
To play a major role in the work of the Research Group, through the conduct of research, introduction of new ideas, dissemination of research results, support and training of others.
To contribute to the strategic development of the Group and of the Division overall.
To be a focus of expertise on bioinformatics.

Main duties:

•  Under the general leadership of the Group Leader, to be responsible for all aspects of the research projects, including defining the direction of the work, conducting the research, analysing the data, preparing the work for publication and disseminating the results at meetings.
•  To present your work at seminars within the Laboratory and at external meetings.
•  To contribute to Laboratory-wide discussions on developments within the Laboratory, particularly in the use of new techniques or new equipment.
•  To contribute to the overall preparation of research for publication.
•  To disseminate research findings in the form of publications, presentations, and reports and thus support the QQR mission of the Division.
•  To identify, develop and apply a broad range of techniques to pursue the research objectives.
•  To keep up to date with developments in the field, proposing or implementing changes of direction as necessary.
•  To work in collaboration with others to achieve joint research projects.
•  To train Students, Postdoctoral Scientist and others and to line manage Group members where appropriate.
•  To contribute to the MRC’s engagement with the public and in the translation of research findings into improvements in health care.

Key Responsibilities:

The key responsibility is to undertake cutting edge research, aimed at key questions within the remit of the Research Group.  You will be expected to provide the intellectual energy and independent thinking necessary to deliver the research and to play a major role in shaping the overall aims and success of the Group.
You will be expected to have the skill and understanding to be able to act independently in solving problems, many of which may require novel approaches.  This will require the integration of different activities to ensure the successful delivery of the research projects.
To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches. 
To interact effectively with a wide range of Staff, Students and others to ensure the smooth running of the Research Group. This will include setting an example in the effective use of resources, training others in methods and use of equipment and taking responsibility for the use of communal facilities. 
To take on responsibility for managing equipment.
To write scientific papers and to present at internal meetings and at conferences.
To ensure the research is conducted in accordance with good practice and in compliance with local policies and legal requirements.
To recognise opportunities for the creation of intellectual property and to cooperate in patent protection and in exploitation.
To secure appropriate external funding and hence staffing and resources for the project, to include preparing grant applications for external funding and developing protocols. 
To manage existing collaborations, and establish new collaborations, both within the Division and the LMB and with external establishments.
To demonstrate a broad balanced and informed perspective of current scientific issues especially those pertaining directly to the area of bioinformatics.
To agree the overall strategic direction of your research. You will be expected to take managerial and budgetary responsibility for your research projects, especially the procurement of external funding.

Working relationships: 

You will report to Prof Julian Gough and will liaise with other Research Support Staff, Postdoctoral Scientists and Students, not only in your Group, but also and across the LMB and with external collaborators. 

Line management responsibilities will be undertaken; these responsibilities, to include Staff development and performance management, should be applied in accordance with the MRC’s policies and procedures. Training will be given if necessary.

You will coordingate and liaise with national and international research consortia such as InterPro and Genome3D.



Investigator Scientist

Overall purpose:

To work within the Group of Prof Julian Gough at the Laboratory of Molecular Biology (LMB).
To lead one or more projects within an overall programme on protein domains and genomics.
There is established research in the group on protein structure domains (SUPERFAMILY), protein disorder (D2P2), protein function and phenotype (dcGO) and other areas such as genetic variation (FATHMM). This project is to bring together our previous research in these areas and unite it into a coherent system for conducting genomic research.
To play a major role in the work of the Research Group, through the conduct of research, introduction of new ideas, dissemination of research results, support and training of others.
To be a focus of expertise on bioinformatics.

Main duties:

•  Under the general leadership of the Group Leader, to be responsible for all aspects of the research projects, including defining the direction of the work, conducting the research, analysing the data, preparing the work for publication and disseminating the results at meetings.
•  To present your work at seminars within the Laboratory and at external meetings.
•  To contribute to Laboratory-wide discussions on developments within the Laboratory, particularly in the use of new techniques or new equipment.
•  To identify, develop and apply a broad range of techniques to pursue the research objectives.
•  To keep up to date with developments in the field, proposing or implementing changes of direction as necessary.
•  To prepare the research for publication.
•  To work in collaboration with others to achieve joint research projects.
•  To train Students, Postdoctoral Scientists and others and to line manage Group members where appropriate.
•  To contribute to the MRC’s engagement with the public and in the translation of research findings into improvements in health care.

Key Responsibilities:

The key responsibility is to undertake cutting edge research, aimed at key questions within the remit of the Research Group.  You will be expected to provide the intellectual energy and independent thinking necessary to deliver the research and to play a major role in shaping the overall aims and success of the group.
While some advice will be available from others in the Laboratory, you will be expected to have the skill and understanding to be able to act independently in solving problems, many of which may require novel approaches.  This will require the integration of different activities to ensure the successful delivery of the research projects.
To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches.
To interact effectively with a wide range of Staff, Students and others to ensure the smooth running of the Research Group. This will include setting an example in the effective use of resources, training others in methods and use of equipment and taking responsibility for the use of communal facilities.
To potentially take on specific responsibilities for managing equipment.
To write scientific papers and to present at internal meetings and at conferences.  
To ensure the research is conducted in accordance with good practice and in compliance with local policies and legal requirements.
To recognise opportunities for the creation of intellectual property and to cooperate in patent protection and in exploitation.
To identify new equipment which will assist the Group programme and to present argued cases for new purchases.
To identify opportunities for additional funding and to apply for external grants where appropriate.

Working relationships:

You will report to Prof Julian Gough and will liaise with other Research Support Staff, Postdoctoral Scientists and Students, not only in your Group, but also across the LMB and with external collaborators including e.g. the InterPro consortium.

Where line management responsibilities are undertaken, these responsibilities, including staff development and performance management, should be applied in accordance with the MRC’s policies and procedures. Training will be provided if required.


Senior Investigator Scientist


Education / Qualifications / Training required: 


Essential: PhD in a biological, computational or other relevant science subject.
Desirable: An undergraduate degree in a subject complimentary or cross-disciplinary to the PhD. E.g. a computational undergraduate degree with a biological PhD or vice versa is desirable.

Previous work experience required:


Essential: Substantial postdoctoral research experience in bioinformatics research.


Desirable: 
•  Direct experience in development and application to research of similar bioinformatics tools and resources to those already in the Group. 
•  Demonstrated leadership in running an international resource.


Knowledge and experience: 

Specific Research Skills 
Essential: Experience in programming.
Desirable: Programming experience in PERL, Python, MySQL, Linux.

Creativity and Initiative
Essential: 
•  Significant experience and results in cutting edge research. 
•  Has developed new techniques/methodologies which have added value to scientific work. 
•  You will have achieved scientific recognition in the relevant field.

Desirable: Has produced or released research tools or resources that are used widely by others.

Independent working
Essential: Proven skills in working independently to solve problems.
Desirable: Proven ability to take the lead on managing a large and complex project.

Verbal and written communication skills
Essential: 
•  Considerable experience in presenting scientific work, both written and orally. 
•  Significant publication record, including first author publications in relevant field.

Desirable: Has experience running workshops and presenting at international conferences.

Mentoring
Essential: Has significant experience of training others "on the job". 

Desirable: 
•  Line management experience.
•  Has experience working with PhD students.

Collaborations/ Influencing Skills
Essential: Has strong skills and experience in working collaboratively within this specific scientific research field.


Desirable: 
•  Has experience working cooperatively with an international consortium. 
•  Has experience working within a wider research community and making contributions recognised by that community.

Intellectual Property
Essential: Understanding of how research activities are affected by and will impact on MRC’s mission statements on knowledge transfer.
Desirable: Understanding of open (and commercial) software licensing and how it impacts research.

Personal skills/behaviours/qualities:


Essential: 
•  Excellent standards of Research Conduct
•  Highly-motivated
•  Strong team player
•  Capable of taking independent decisions
•  Collaborative


Investigator Scientist

Academic qualifications and experience:

PhD in a biological, computational or other relevant science subject
Significant postdoctoral research experience in bioinformatics research.

Technical skills and expertise:

Experience of and proven ability to perform techniques relevant to the project, and knowledge of the field.  Particularly useful would be experience of computational research.
Experience of bioinformatics research would beneficial.
Experience doing research including databases and tools and resources would also be beneficial.

Track record of research:

This will include substantial discoveries and achievements, and significant contributions to published papers.
Demonstrated ability to conceive own project ideas and carry them out to completion.
It would be desirable to have proven skills in managing international or distance collaborations with an external team.

Other relevant evidence of:

•  Commitment.
•  Originality.
•  Ability to communicate effectively.
•  Strong team player.

Additional information:

The post is available to applicants with varying computational experience. Applicants with no formal training in computational or mathematical work but who enjoy it, have self-taught to a high level, have a strong aptitude for it and are keen to learn will be considered, if they have other complimentary biological qualifications, knowledge and experience. Conversely computer or technical scientists with no formal training in molecular biology research will be considered if they have a powerful interest and motivation in molecular biology and are driven to learn.


The successful candidate will be appointed as an Investigator Scientist or a Senior Investigator Scientist. Starting Salary and the position appointed to will be dependent on research experience. 

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.


The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.


Choosing to come to work at the MRC means that you will have access to a whole host of benefits from a final salary pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme and childcare vouchers, as well as the chance to put the MRC on your CV in the future.

 

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

 

Final appointments will be subject to pre-employment screening.