View Vacancy -- Investigator Scientist - Structural Studies - Dr Jan Löwe - LMB 497
The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years.
There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.
With the new laboratory the LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.
To work within the Group of Jan Löwe at the Laboratory of Molecular Biology (LMB).
To lead one or more projects within an overall programme on aimed at an elucidation of the molecular mechanism of the eukaryotic cohesin complex. This will mainly involve structure determination of cohesin holo-complexes or sub-complexes, most likely by cryoEM. Expression systems are available or will have to be developed, depending on progress of the structure determination. All of this will be in collaboration with Kim Nasmyth's group in Oxford who will be able to provide significant support in the biology of cohesin as well as providing constructs and proteins.
To play a major role in the work of the Research Group, through the conduct of research, introduction of new ideas, dissemination of research results, support and training of others.
To be a focus of expertise on the expression, purification and cryoEM imaging of Smc complexes.
• To undertake research aimed at an elucidation of cohesin's molecular mechanism in chromosome biology.
• Under the general leadership of the Group Leader, to be responsible for all aspects of the research projects, including defining the direction of the work, conducting the research, analysing the data, preparing the work for publication and disseminating the results at meetings.
• To present your work at seminars within the Laboratory and at external meetings.
• To contribute to Laboratory-wide discussions on developments within the Laboratory, particularly in the use of new techniques or new equipment.
• To identify, develop and apply a broad range of techniques to pursue the research objectives.
• To keep up to date with developments in the field, proposing or implementing changes of direction as necessary.
• To prepare the research for publication.
• To work in collaboration with others to achieve joint research projects.
• To train Students, Postdoctoral Scientists and others and line management of Group members where appropriate.
• To contribute to the MRC’s engagement with the public and in the translation of research findings into improvements in health care.
The key responsibility is to undertake cutting edge research, aimed at key questions within the remit of the Research Group. You will be expected to provide the intellectual energy and independent thinking necessary to deliver the research and to play a major role in shaping the overall aims and success of the group.
While some advice will be available from others in the Laboratory, you will be expected to have the skill and understanding to be able to act independently in solving problems, many of which may require novel approaches. This will require the integration of different activities to ensure the successful delivery of the research projects.
To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches.
To interact effectively with a wide range of Staff, Students and others to ensure the smooth running of the Research Group. This will include setting an example in the effective use of resources, training others in methods and use of equipment and taking responsibility for the use of communal facilities.
To potentially take on specific responsibilities for managing equipment.
To write scientific papers and to present at internal meetings and at conferences.
To ensure the research is conducted in accordance with good practice and in compliance with local policies and legal requirements.
To recognise opportunities for the creation of intellectual property and to cooperate in patent protection and in exploitation.
To identify new equipment which will assist the Group programme and to present argued cases for new purchases.
To identify opportunities for additional funding and to apply for external grants where appropriate.
Where line management responsibilities are undertaken, these responsibilities, including staff development and performance management, should be applied in accordance with the MRC’s policies and procedures. Training will be provided if required.
You will report to Dr Löwe and will liaise with other Research Support Staff, Postdoctoral Scientists and Students, not only in your Group, but also across the LMB and with external collaborators.
PhD in a biological subject.
Significant postdoctoral research experience in modern cryoEM and/or protein crystallography.
Technical skills and expertise:
Experience of and proven ability to perform techniques relevant to the project, and knowledge of the field. Particularly useful would be experience of with single particle electron microscopy.
Track record of research:
This will include substantial discoveries and achievements, and significant contributions to published papers.
Other relevant evidence of:
• Ability to communicate.
• Working with others.
Experience in X-ray crystallography is required with a strong background in molecular biology and structural biology.
The MRC is a great place to work and progress your career, be it in scientific research or the support functions.
The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.
Choosing to come to work at the MRC means that you will have access to a whole host of benefits from a final salary pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme and childcare vouchers, as well as the chance to put the MRC on your CV in the future.
Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.
Final appointments will be subject to pre-employment screening.