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View Vacancy -- Research Support Assistant - Structural Studies - Andrew Carter - LMB 607

Open Date
25/07/2017, 14:35
Close Date
26/08/2017, 23:55
MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

With the new laboratory the LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

MRC - 5
£21,951 - £25,718
Fixed Term
Full Time
1 year
Overall purpose:
To assist researchers in preparing, performing, and evaluating experiments under the guidance of the Group Leader at the MRC Laboratory of Molecular Biology (LMB).

To work within a programme aimed at the characterization of the cytoplasmic dynein complex.  Specifically, to use baculovirus and mammalian expression system to assist in the production of proteins that are cargos, accessory factors and regulators of dynein.

Main duties/Key Responsibilities:
To develop strategies for the production of challenging multi protein complexes for structural and biochemical analysis.  

Responsibilities will include all steps of protein production i.e. growth and maintenance of insect and mammalian cell lines, cloning, protein expression and protein purification. They will also involve purification of complexes from native sources.

Within the objectives of the project you will carry out the project with the supervision of a Postdoctoral Scientist.

To plan your own work and objectives on a weekly basis and to manage your experimental work within the project along with your supervisor.

To discuss progress and plans on a regular basis with your supervisor and members of the group.

To ensure the research is carried out in accordance with good practice and in compliance with local polices and legal requirements.

To contribute to the smooth running of the research group, including the effective use of resources and taking responsibility for use of communal facilities.

To enhance your research and generic skills through a tailored development programme.

Working relationships:
You will report to the Group Leader, Dr Andrew Carter. You will interact and collaborate with Postdoctoral Scientists, Research Support Staff and Students in the Group and across the LMB, and with external Groups as necessary.

Education / qualifications / training required:

Essential: BSc or higher level qualification in a relevant field of the life sciences.

Previous work experience required:

•    Experience of working in biological research labs.
•    Experience in mammalian cell culture, insect cell culture or protein purification.

Desirable: Previous experience of laboratory research would be an advantage, but training will be given.

Knowledge and experience:

Creativity and initiative
Essential: Have the ability to plan and carefully execute experiments.

Desirable: Ideally, should have shown those skills in a team environment.

Independent working
Essential: Proven skills in working independently to solve experimental problems.

Desirable: Ideally, being able to develop protocols/procedures independently.

Verbal and written communication skills
Essential: Experience in presenting scientific work, both written and orally.

Desirable: Has made contributions to scientific papers.

Personal skills / behaviours / qualities:

Essential: Motivated individual with a strong desire for self and team development.  

•    A curiosity about science.
•    Interest in a scientific career.

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.

The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

Final appointments will be subject to pre-employment screening.

This opportunity is closed to applications.