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View Vacancy -- Scientific Researcher - Cell Biology - Liz Miller - LMB 611

Open Date
25/07/2017, 15:35
Close Date
28/08/2017, 23:55
MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies.  The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease.  We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology.  However, scientific collaboration between the different Divisions is extensive.  Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

With the new laboratory the LMB provides an unsurpassed environment for both new and established researchers.  Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

MRC - 4
Fixed Term
Full Time
12 Months

Overall purpose:

To work within the Group of Dr Elizabeth Miller at the MRC Laboratory of Molecular Biology (LMB), on a programme investigating protein quality control within the secretory pathway, focusing on early events in protein biosynthesis in the endoplasmic reticulum (ER) and export from the ER via transport vesicles. Specifically to undertake research to investigate intracellular traffic in yeast and human tissue culture cells.

To play a major role in the work of the Research Group, through the conduct of research, introduction of new ideas, dissemination of research results and the support and training of others.

Main duties:

•   To undertake research aimed at dissecting the role of the COPII cargo adaptor protein, Sec24, in export from the ER of client proteins in yeast and human cell culture models.
•   To identify, develop and apply a broad range of biochemical and genetic techniques to pursue the research objectives.
•   To present scientific work at seminars within the Laboratory and at external meetings.
•   To contribute to Laboratory-wide discussions on developments within the field.
•   Where appropriate, to draft scientific papers, and contribute to the overall preparation of research for publication.
•   To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.
•   To assist in the training of PhD students and other members of the LMB.

Key responsibilities:

To plan your own work and objectives and manage your experimental work within the project along with your Supervisor.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.

To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.

To apply for independent funding opportunities as they arise, with assistance and input from your Supervisor.

Working relationships:

You will report to Dr Miller and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.

Additional information:

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC.

Academic qualifications:
PhD in a relevant biological subject or due to complete doctoral studies within 6 months of applying (in a biological subject).

Technical skills and expertise:
Experience of and ability to perform techniques relevant to the project, including basic molecular biology and biochemistry experiments.

In particular experience of working with yeast genetics and biochemistry, mass spectrometry approaches to protein identification and characterization as well as cell culture is a necessity.

Track record of research:
This will include achievements, and a strong publication record relative to career stage, including evidence of manuscript preparation. Evidence of research presentations in the form of posters and talks is also expected.

Other relevant evidence of:
•   Commitment.
•   Originality.
•   Ability to communicate.
•   Working with others.
•   Time management skills.

Additional information:
The candidate should be able to work collaboratively within a team, while also having the resourcefulness to carry out aspects of the project independently. Evidence of collaborative work e.g. collaborative publications is desirable.

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.

The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

Final appointments will be subject to pre-employment screening.

This opportunity is closed to applications.