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Leading science for better health

View Vacancy -- Cellular Electron Microscopy Specialist - Cell Biology - Dr Ben Nichols - LMB 695

Open Date
30/10/2017 10:00
Close Date
29/11/2017 23:55
MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

With the new laboratory the LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

MRC - 4
Cambridge
Band 3 £37,769 - £51,023 Band 4 £30,464 - £38,931
Permanent
Science
Full Time

Band 3 (£37,769 - £51,023)

Overall purpose:

To carry out high level technical support for cellular electron microscopy based experiments, and other types of experiments should the need arise, for multiple groups in the Cell Biology Division and in other divisions of the MRC Laboratory of Molecular Biology (LMB).

To provide expertise, advice and to collaborate with and support other members of the group with the mutual aim of learning, adapting, developing, improving and applying methods for electron microscopy within the research programme of the group.

You will take responsibility for the implementation, optimisation and development of methods and instrumentation for electron microscopy. In collaboration with the staff of the world-class electron microscopy (EM) facility, you will maintain and develop electron microscopy capabilities at the LMB, and provide support to scientific staff who wish to perform electron microscopy.

You will also take on other communal responsibilities contributing to the smooth running of the research group as identified by the Programme Leader.

Main duties:

•   To liaise with different research groups and discuss applications of electron microscopy.
•   To provide expertise and advice to multiple groups / projects in applying tomographic imaging and correlative light and electron microscopy.
•   To prepare samples and carry out electron microscopy and different types of experiment as the scientific need arises.
•   To manage complex infrastructure for electron microscopy within the Cell Biology Division, including ultra-microtomy and high pressure freezing equipment, as well as preparation and management of reagents and other resources.
•   To identify, develop and apply a broad range of electron microscopy techniques to pursue the research objectives.
•   To present scientific work at seminars within the Laboratory and at external meetings.
•   To contribute to lab-wide discussions on developments within the field.
•   To help prepare scientific papers, and contribute to the overall preparation of research for publication.
•   To assist in the training of PhD students and other new users in advanced electron microscopy techniques.
•   To Line Manage a Band 5 Research Support Assistant.

Key responsibilities:

•   Independent management of extensive internal collaborations.
•   To introduce and apply new techniques, and develop novel approaches and methods where required.
•   To ensure the research is carried out in accordance with good practice and in compliance with local polices and legal requirements.

Working relationships:

You will report to Dr Nichols and will interact and collaborate with other Group Leaders, Postdoctoral Scientists, Research Support staff and Students in the Division and across the LMB, and with external Groups as necessary.

Additional information:

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC.  

Band 4 (£30,464 - £38,931)

Overall purpose:

To carry out high-level technical support for cellular electron microscopy based experiments, and other types of experiments should the need arise, for multiple groups in the Cell Biology Division and in other divisions of the MRC Laboratory of Molecular Biology (LMB).

Main duties:

•   To liaise with different research groups and discuss applications of electron microscopy.
•   To provide support to multiple groups / projects in applying tomographic imaging and correlative light and electron microscopy.
•   To prepare samples and carry out electron microscopy and different types of experiment as the scientific need arises.
•   To manage infrastructure for electron microscopy within the Cell Biology Division, including ultra-microtomy and high pressure freezing equipment, as well as preparation and management of reagents and other resources.
•   To identify, develop and apply a broad range of electron microscopy techniques to pursue the research objectives.
•   To present scientific work at seminars within the Laboratory and at external meetings
•   To contribute to lab-wide discussions on developments within the field.
•   Where appropriate, to help draft scientific papers, and contribute to the overall preparation of research for publication.
•   To assist in the training of new users in advanced electron microscopy techniques.

Key responsibilities:

•   To plan your own work and objectives and manage their experimental work within the projects along with their supervisor.
•   To introduce and apply new techniques, and develop novel approaches and methods where required.
•   To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

Working relationships:

You will report to Dr Nichols and will interact and collaborate with other Group Leaders, Postdoctoral Scientists, Research Support staff and Students in the Division and across the LMB, and with external Groups as necessary.

Additional information:

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC.  

Band 3 (£37,769 - £51,023)

Education / qualifications / training required:

Essential: PhD in a relevant subject or equivalent research experience.  
Desirable: Skills in molecular cell biology and/or cell culture.

Previous work experience required:

Essential:
•   Extensive experience in electron microscopy of biological samples.
•   Excellent knowledge of electron microscopy hardware and software including an understanding of electron physics, optics, and microscope control software.
•   Extensive experience of providing research support in a scientific laboratory.
•   Has experience of training others  “on the job”.

Desirable: Western blotting, molecular cloning, tissue culture.

Knowledge and experience:

Creativity and initiative
Essential:
•   Can demonstrate problem-solving approaches and ability to design own experiments.
•   Experience in developing and applying novel technical approaches in electron microscopy.
•   Experience in resource management and providing technical support.

Desirable:
•   Has developed new techniques/methodologies in the area of electron microscopy, which have added value to scientific work.
•   An awareness of health and safety issues.

Independent working
Essential:
•   Experience of independent collaborative project management.
•   Proven skills in working independently to solve problems.
•   Ability to independently carry out an experimental programme, including design, analysis and write-up.
•   Ability to perform experiments accurately using a defined protocol.

Desirable: Able to acquire new techniques quickly and independently.

Verbal and written communication skills
Essential:  
•   Excellent verbal and written communication skills.
•   Experience in giving presentations, both written and orally.

Desirable:  Track-record of written contribution to scientific publications, and presentation of data at internal and external meetings.

Personal skills / behaviours / qualities:

Essential:
•   Good time management, with an ability to be self-motivated, while working in a small team and having to re-prioritise a demanding workload under pressure.
•   Excellent standards of research conduct.
•   Excellent interpersonal and communication skills.
•   Ability to communicate at all levels of technical complexity with both novice and advanced users.
•   Proven ability to work patiently and methodically for long periods to acquire large high-quality datasets.

Desirable:
•   Ability to inspire and encourage other staff members.
•   Ability to write complex and comprehensive scientific reports.

Band 4 (£30,464 - £38,931)

Education / qualifications / training required:

Essential: PhD in a relevant subject or directly equivalent research experience.  
Desirable: Skills in molecular cell biology and/or cell culture.

Previous work experience required:

Essential: Extensive experience in electron microscopy of biological samples.

Desirable:
•   Excellent knowledge of electron microscopy hardware and software including an understanding of electron physics, optics, and microscope control software.
•   Detailed knowledge of electron microscopy.
•   Western blotting, molecular cloning, tissue culture.

Knowledge and experience:

Creativity and initiative
Essential: Intellectual understanding of rationale and data interpretation in previous research projects.

Desirable:
•   Can demonstrate problem-solving approaches and ability to design own experiments.
•   Experience in resource management and providing technical support.
•   Has experience of training others “on the job”.

Independent working
Essential: Responsible, diligent and accurate approach with the ability to work under limited supervision.
Desirable: Experience of managing own project.

Verbal and written communication skills
Essential: Good verbal and written communication.
Desirable: Experience of scientific writing.

Personal skills / behaviours / qualities:

Essential:
•   Motivated individual with a strong desire for self and team development.
•   Excellent standards of research conduct.
•   Excellent interpersonal and communication skills.
•   Ability to communicate at all levels of technical complexity with both novice and advanced users.
•   Strong skills and experience in working collaboratively as a member of a team.

Desirable: Proven ability to work patiently and methodically for long periods to acquire large high-quality datasets.


From April 2018, MRC will be part of UK Research and Innovation. UK Research and Innovation will bring together the seven Research Councils, Innovate UK and a new organisation, Research England. The vision for the new organisation is to be the best research and innovation organisation in the world. From 1 April 2018 your employer will be UK Research and Innovation. More information can be found online http://www.ukri.org/ .

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.


The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.


Choosing to come to work at the MRC means that you will have access to a whole host of benefits from a final salary pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme and childcare vouchers, as well as the chance to put the MRC on your CV in the future.

 

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

 

Final appointments will be subject to pre-employment screening.