View Vacancy -- Bioinformatician / Biostatistician - LMS 708

Open Date
08/11/2017, 14:20
Close Date
17/12/2017, 23:55
MRC London Institute of Medical Science
The London Institute of Medical Sciences (LMS) at Hammersmith Hospital is the third directly funded MRC research institute and enjoys close links with its partners at Imperial College and at the Imperial College Healthcare NHS Trust. The LMS research focuses on strengthening the basic science underpinning our understanding of human diseases and the translation of such high quality research into a clinical setting.
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MRC - 4
£34,988 to £37,801
Fixed Term
Full Time
3 years

Overall purpose:


The London Institute Of Medical Sciences (LMS) at Hammersmith Hospital is the third directly funded MRC research institute and enjoys close links with its partners at Imperial College and at the Imperial College Healthcare NHS Trust. The LMS's research focuses on strengthening the basic science underpinning our understanding of human diseases and the translation of such high quality research into a clinical setting. Within the LMS the Bioinformatics facility works closely with both research groups and facilities to meet the bioinformatics requirements of the institute. The post is part of the LMS Bioinformatics facility and will work closely with the state of the art Proteomics facility to establish best practice in proteomics data acquisition, processing and analysis. The primary responsibilities will be experimental design, establishing of bioinformatics workflows and analysis of bioinformatics data. This work will be carried out in collaboration with the LMS research groups as well assisting in the development and maintenance of the infrastructure of the Bioinformatics Proteomics facilities and the training of bioinformatics techniques within the institute.


Main duties / key responsibilities

  • To analyse a diverse range of biological data for LMS members.
  • To develop novel tools and techniques to analyse biological datasets
  • To develop expertise in the analysis of hyphenated mass spectrometry-based ‘omics’ data sets with a focus on proteomics and metabolomics data
  • To communicate bioinformatics analysis and statistics principals to postgraduates, research scientists and principal investigators.
  • To ensure the validity and reliability of data and statistics methods at all times.
  • To maintain accurate and complete records of analysis projects.
  • To identify and develop suitable techniques for the analysis and visualisation of data, and to build and maintain the associated computational resources (software packages, databases, or web-based analysis and visualisation tools).
  • To maintain all code and programs used for analysis and tool development with suitable source control.
  • To assist in the administration of the Bioinformatics facility’s proteomics computational infrastructure.
  • To work with the Proteomics facility staff in maintaining and developing computational infrastructure and data analysis workflows
  • To identify and implement present and upcoming infrastructure requirements for the Bioinformatics team and proteomics data acquisition and analysis.
  • To assist in and develop bioinformatics training for postgraduate research students and research assistants.
  • To assist with the submission of proteomics data sets to public repositories (such as the PRoteomics IDEntifications database, PRIDE)
  • To present bioinformatics tools and techniques to colleagues.
  • To attend relevant workshops and conferences as necessary.
  • To participate in Bioinformatics and Proteomics Facility meetings and internal seminars.
  • To contribute to the smooth running of the Bioinformatics facility.To comply with the College, Division, and Unit safety practices and to attend courses on safety when appropriate.


Other Duties

  • To undertake appropriate administration tasks.
  • To attend relevant meetings.
  • To undertake any necessary training and/or development.
  • Any other duties commensurate with the grade of the post as directed by the supervisor.

Education / Qualifications / Training required:


  • PhD in Computational Biology, Biostatistics, Bioinformatics or Biological Sciences or equivalent research, industrial or commercial experience

Knowledge and experience:


  • Knowledge of molecular biology and genomics.
  • Experience with bioinformatics/biostatistical techniques and tools used in molecular biology and genomics.
  • Experience in using R and Bioconductor packages in the analysis of biological data.
  • Proficiency in the acquisition and analysis of high throughput proteomics data or showing potential to develop and apply the required skills for analysis of such data.


  • Evidence of a high level of skill in at least one general programming language (Python, Java or C++ are preferred)
  • Evidence of working on statistical software (SAS, R, SPSS)
  • Previous experience with ‘omics’ data analysis and associated computational platforms (such as Perseus)
  • Proven ability in software development and the collaborative use of source control
  • Experience in training biologists and bioinformaticians in the use of bioinformatic tools
  • Track record of contribution to peer reviewed publications
  • Proficiency in web programming (Ruby on Rails, Django, Javascript)
  • Experience building and managing MySQL databases

Personal skills/behaviours/qualities:


  • Willingness to work closely with colleagues to seek solutions to Bioinformatics and Proteomics facilities’ goals
  • High level of motivation and drive
  • Willingness to share knowledge and skills with other members of the team on a daily basis.
  • Flexible attitude towards work
  • Discipline and regard for confidentiality and security at all times
  • Willingness to undertake any necessary training for the role
  • Willingness to travel both within the United Kingdom and abroad to conduct research and attend conferences

If you would like to talk about the facility and/or working at the LMS in a more general way please contact Dr Mehdi Karimi (Head of Bioinformatics facility)  or Dr Yi-Fang Wang (female bioinformatician in the facility) .


The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.

We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.

This opportunity is closed to applications.