View Vacancy -- Research Support Assistant - PNAC - Genotyping - LMB 930

Open Date
02/10/2018, 12:00
Close Date
16/10/2018, 23:55
MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies.  The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease.  We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology.  However, scientific collaboration between the different Divisions is extensive.  Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

The LMB provides an unsurpassed environment for both new and established researchers.  Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

MRC - 5
22,201 - 25,976
Fixed Term
Full Time
1 Year

Overall purpose:

To work within the Laboratory of Molecular Biology (LMB) Genotyping Service team. The service provides high throughput genotyping of transgenic mice to facilitate LMB research programmes. You will focus on genotyping, using block based and real time PCR methods.

Main duties:

You will need to implement successfully a range of molecular biology procedures required for the genotyping of transgenic mice.  This requires:
• Processing DNA samples.
• Block based and real time Polymerase chain reaction (PCR) setup and analysis.
• Use and maintenance of automated systems.
• Transmission of results to various research groups responsible for the mouse lines.
• Quality control and assessment of all data, to maintain standards.
• Optimisation of new protocols required by researchers.
• Maintenance of database records and archives of data and samples.
• Maintenance of records of all work undertaken.
• Liaising with both LMB researchers and animal facility staff to ensure the smooth running of the facility.
• Occasional weekend and out of hours work may be required on a rota basis.

Key responsibilities:

You will be responsible for providing research support for the Transgenic Facility, enabling the facility to provide a variety of services to the LMB. This will involve:
• Implementation of the techniques listed above to a very high standard.
• Responsibility for the quality and maintenance of standards of your own work.
• Organisation of your own work, and to work in collaboration with the team so that all the needs of the Transgenic Facility are met within an appropriate timeframe.
• Maintenance of accurate records of your own work.
• From time to time you will be expected to take on lab-wide tasks that are shared among the research support category. These could involve participation in the development of local rules and procedures and ensuring compliance by other members of the laboratory.
• You will be expected to contribute to lab-wide discussions on developments within the laboratory, particularly in the use of new techniques or new equipment.

Working relationships:

The line manager for this post is the Genotyping Manager. You will also work closely with other groups within the LMB, and will liaise with animal facility staff.

Additional information:

The above lists are not exhaustive and you are required to undertake such duties which may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC. 

Education / qualifications / training required:

Essential: Degree or equivalent in a biological subject.

Previous work experience required:

• Some experience of working in a molecular biology based role.
• Practical experience and proficiency in block based and/or real time PCR.
• Experience of working effectively within a team to achieve a common goal.
• Experience of handling large quantities of data.

• Report writing.
• Managing databases.
• Some experience of working in a high throughput research support team using automated systems.

Knowledge and experience:  

Creativity and initiative:
Essential: Can identify and solve problems, drawing on previous experience and initiative.

Desirable: Readily undertakes implementation of new procedures and protocols for use within the team.

Independent working Essential:  
• Demonstrates strong organisational skills.
• Has experience in managing own workload and objectives.

Verbal and written communication skills:
Essential: Demonstrates excellent verbal and written communication skills both within and outside of a team.

Personal skills / behaviours / qualities:

• Strong skills in both collaborative and independent working.
• Understands the necessity of working to very high standards.
• Demonstrates motivation, integrity and responsibility.

• Experience of working with little supervision on a scientific project.
• Good judgement in assessing when to ask for support.
• Demonstrates persistence in problem solving.

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

UKRI supports research in areas that include animal health, agriculture and food security, and bioscience for health which includes research on animals, genetic modification and stem cell research. Whilst you may not have direct involvement in this type of research, you should consider whether this conflicts with your personal values or beliefs.

We will conduct a full and comprehensive pre-employment check as an essential part of the recruitment process on all individuals that are offered a position with UKRI. This will include a security check and an extreme organisations affiliation check.

This opportunity is closed to applications.