Leading science for better health

View Vacancy -- Senior Electron Microscope Engineer/ Electron Microscope Engineer - Structural Studies - Dr John Briggs - LMB 957

Open Date
29/10/2018, 10:00
Close Date
26/11/2018, 23:55
MRC Laboratory of Molecular Biology

The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies.  The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease.  We aim to tackle difficult, long-term problems, which often require investment over many years.


There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology.  However, scientific collaboration between the different Divisions is extensive.  Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.


The LMB provides an unsurpassed environment for both new and established researchers.  Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at www.ukri.org

MRC - 3
Cambridge
£27,906 - £44,396*
Permanent
Technical & Scientific Professionals
Full Time

An Electron Microscope Engineer position is available at MRC Laboratory of Molecular Biology (LMB) and appointments will be made at either band 3 Senior Electron Microscope Engineer or band 4 Electron Microscope Engineer depending on experience. Please see below for full Job Descriptions and Person Specifications for the roles.

Band 3 Senior Electron Microscope Engineer

*Starting salary £37,769 - £44,396, Band salary £37,769 - £51,023

Overall purpose:

The LMB has a world-leading Electron Microscopy (EM) facility including three Titan Krios, two Polara, two 200kV FEG microscopes, one Scios dual-beam SEM and Tecnai Spirit electron microscopes. The facility hosts research programmes aimed at the development of new hardware and software for cryo-electron microscopy and has approximately 150 active users applying electron cryomicroscopy and cryo-electron tomography to study important biological problems.

The primary purpose of the Senior EM Engineer is to maintain and improve the world-leading EM facility through service, maintenance, optimisation and development of microscope hardware and software. You will also provide expertise, advice and support to other members of the Laboratory.

Main duties & Key Responsibilities:

To maintain and service microscope hardware and software drawing on expertise and knowledge to ensure the microscopes are available in optimal condition.

To collaborate with LMB scientists on research projects aimed at improving the performance, efficiency and usability of the electron microscopes through modification of software or hardware. As appropriate, sustain and steer such projects.

To provide guidance to facility staff that helps them to provide assistance and trouble-shooting to microscope users taking balanced decisions and offering solutions as appropriate.

To develop “best-practice” protocols for microscope use and ensuring that facility staff are kept informed of them.

To establish and implement a defined maintenance programme, and performance assessment programme for electron microscopes, configuring and installing new instrumentation and software as required.

To facilitate Service Engineer visits. This will include interacting with engineers from microscope manufacturers including Thermo Fischer (formerly FEI) to keep the microscopes maintained under optimal conditions, actively ensuring that any matters of concern are addressed adequately and providing feedback to the EM Facility Manager.

To ensure continued development of technical knowledge through personal development specifically you will work closely with the microscope companies to maintain an up-to-date knowledge of microscope maintenance and service.

To work constructively with the Research Support Assistants and the EM Facility Manager as part of the team that ensures the smooth operation of the EM facility.

You will additionally be expected to:

Keep up to date with developments in the field, proposing or implementing changes of direction as necessary.

Maintain a deep personal knowledge of the systems within the EM facility.

Introduce, apply and develop new techniques across a wide range of disciplines.

Contribute to lab-wide discussions on developments within the laboratory, particularly in the use of new techniques.

Interact effectively with a wide range of staff, students and others to ensure the smooth running of research.

Take on other communal responsibilities contributing to the smooth running of research.

Working relationships:

You will work in a team with the EM Facility Manager and the two EM Research Support Officers. The facility is overseen by a Group Leader. You will liaise with other Group Leaders, Research Support staff, Post-doctoral Scientists and Students across the LMB and with external collaborators. Use of the facility is driven by academic demand.

Additional information:

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC. 

Band 4 Electron Microscope Engineer

*Starting salary £27,906 - £33,305, Band salary £27,906 - £38,931

Overall purpose:

The LMB has a world-leading EM facility including three Titan Krios, two Polara, two 200kV FEG microscopes, one Scios dual-beam SEM and Tecnai Spirit electron microscopes. The facility hosts research programmes aimed at the development of new hardware and software for cryo-electron microscopy and has approximately 150 active users applying electron cryomicroscopy and cryo-electron tomography to study important biological problems.

The primary purpose of the EM Engineer is to maintain and improve the world-leading EM facility through service, maintenance, optimisation and development of microscope hardware and software. You will also provide advice and support to other members of the Laboratory.

Main duties & Key Responsibilities:

To maintain and service microscope hardware and software.

To collaborate with LMB scientists on research projects aimed at improving the performance, efficiency and usability of the electron microscopes through modification of software or hardware.

To assist other facility staff in providing high-level assistance and trouble-shooting to microscope users.

Together with other facility staff, to develop “best-practice” protocols for microscope use.

To establish and implement a defined maintenance programme, and performance assessment programme for electron microscopes, configuring and installing new instrumentation and software as required.

To arrange and facilitate Service Engineer visits. This will include interacting with engineers from microscope manufacturers including Thermo Fischer (formerly FEI) to keep the microscopes maintained under optimal conditions. You will also work closely with the microscope companies to maintain an up-to-date knowledge of microscope maintenance and service.

To interact with the Research Support Assistants and the EM Facility Manager to ensure the smooth operation of the EM facility.

You will additionally be expected to:

Keep up to date with developments in the field, proposing or implementing changes of direction as necessary.

Maintain a deep personal knowledge of the systems within the EM facility.

Introduce, apply and develop new techniques across a wide range of disciplines.

Contribute to lab-wide discussions on developments within the laboratory, particularly in the use of new techniques.

Interact effectively with a wide range of staff, students and others to ensure the smooth running of research.

Take on other communal responsibilities contributing to the smooth running of research.

Working relationships:

To work in a team with the EM Facility Manager and the two EM Research Support Officers, reporting to the EM Facility Manager. The facility is overseen by a Group Leader. You will liaise with other Group Leaders, Research Support staff, Post-doctoral Scientists and Students across the LMB and with external collaborators. Use of the facility is driven by academic demand.

Additional information:

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post.  All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC. 

Band 3 Senior Electron Microscope Engineer

Education / qualifications / training required:

Essential: Significant experience in the operation and maintenance of transmission electron microscopes or a PhD in electrical engineering, physics, materials sciences or related subject combined with extensive experience in the operation and maintenance of transmission electron microscopes.

Previous work experience required:

Essential:
• Substantial experience in the maintenance, repair and operation of transmission electron microscopes.
• Extensive experience working with high-end transmission electron microscopes manufactured by FEI or Thermo Fisher, or extensive experience working with high-end transmission electron microscopes from another manufacture combined with excellent knowledge of cryo-electron microscopy.

Desirable:
• Experience in the use of cryo-electron microscopy.
• Experience in the provision of user support.
• Some experience in computer programming or scripting.

Knowledge and experience:

Technical skills

Essential:
• Excellent knowledge of transmission electron microscopy including hardware and software.
• The ability to acquire new techniques quickly.
• Good IT skills.

Desirable:
• Detailed knowledge of software used to control electron microscopes.
• Knowledge of the use of cryo-electron microscopy for the determination of the structures of biological samples.
• Experience in the design of technical instrumentation.

Creativity and initiative

Essential: Experience working independently in creative and insightful way to trouble-shoot complex problems.

Desirable: Has developed new techniques/methodologies in the area of electron microscopy, which have added value to scientific work.

Independent working

Essential:
• Ability to work independently, including prioritising, planning, assessing and recording of work performed.
• Able to acquire new techniques quickly and independently.
• The ability to self-motivate, to organise work-time efficiently and to perform work accurately using a defined protocol.

Desirable:
• Has experience of training others "on the job".
• Experience working in an environment where cutting-edge research is performed.
• Experience working with users who are performing cutting-edge research.

Verbal and written communication skills

Essential:
• Experience in writing reports on work performed.
• Ability to write protocols and help-sheets in English.

Desirable: Experience in giving presentations, both written and oral.

Personal skills / behaviours / qualities:

Essential:
• Excellent standards of professional conduct.
• Excellent interpersonal and communication skills with the ability to communicate at all levels of technical complexity with both novice and advanced users, as well as experts including service engineers.
• Strong skills and experience in working collaboratively as a member of a team.
• Excellent time management, with an ability to be self-motivated, while working in a small team and having to re-prioritise.

Band 4 Electron Microscope Engineer

Education / qualifications / training required:

Essential: Experience or training in a relevant area and/or a PhD in engineering, physics, materials sciences or related scientific/technical subject.

Previous work experience required:

Essential:
• Experience in the operation of transmission electron microscopes.
• Experience in the maintenance, repair, or management of transmission electron microscopes.

Desirable:
• Experience working with high-end transmission electron microscopes manufactured by FEI or Thermo Fisher.
• Experience in the use of cryo-electron microscopy.
• Experience in the provision of user support.
• Some experience in computer programming or scripting.

Knowledge and experience:

Technical skills

Essential:
• Knowledge of transmission electron microscopy including hardware and software.
• The ability to acquire new techniques quickly.
• Good IT skills.

Desirable:
• Excellent knowledge of transmission electron microscopy.
• Knowledge of the use of cryo-electron microscopy for the determination of the structures of biological samples.
• Experience in the design of technical instrumentation.

Creativity and initiative

Essential: Experience working independently in creative and insightful way to trouble-shoot complex problems.

Desirable: Has developed new techniques/methodologies in the area of electron microscopy, which have added value to scientific work.

Independent working

Essential:
• Ability to work independently, including prioritising, planning, assessing and recording of work performed.
• Able to acquire new techniques quickly and independently.
• The ability to self-motivate, to organise work-time efficiently and to perform work accurately using a defined protocol.

Desirable:
• Has experience of training others "on the job".
• Experience working with users who are performing cutting-edge research.

Verbal and written communication skills

Essential:
• Experience in writing reports on work performed.
• Ability to write protocols and help-sheets in English.

Desirable: Experience in giving presentations, both written and oral. Personal skills / behaviours / qualities:

Essential:
• Excellent standards of professional conduct.
• Excellent interpersonal and communication skills with the ability to communicate at all levels of technical complexity with both novice and advanced users, as well as experts including service engineers.
• Strong skills and experience in working collaboratively as a member of a team. • Excellent time management, with an ability to be self-motivated, while working in a small team and having to re-prioritise.

The MRC is a great place to work and progress your career, be it in scientific research or the support functions.

The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.

Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We welcome applications from all sections of the community irrespective of gender, race, ethnic or national origin, religion or belief, sexual orientation, disability or age. As "Disability Confident" employers, we guarantee to interview all applicants with disabilities who meet the minimum criteria for the vacancy.

Final appointments will be subject to pre-employment screening.